Research workbench
P1.2 serosubtype antigen derived from N. meningitidis pora in complex with Fab fragment
Analyse P1.2 serosubtype antigen derived from N. meningitidis pora in complex with Fab… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1UWX
- Type
- protein
- Length
- 1,001 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein G-prime; Antibody; Class 1 outer membrane protein variable region 2
- UniProt
- Q54181, Q51220
- Pockets
- 11 · best druggability 0.58
Structure
x-ray diffraction · 5 distinct chains · 11% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein G-prime | protein | 57 | 30% helix, 47% strand | Q54181 |
| B | Protein G-prime | protein | 60 | 23% helix, 45% strand | Q54181 |
| H, M | Antibody | protein | 218 | 8% helix, 52% strand | — |
| K, L | Antibody | protein | 211 | 6% helix, 50% strand | — |
| P, Q | Class 1 outer membrane protein variable region 2 | protein | 13 | 0% helix, 15% strand | Q51220 |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 453 | 0.58 | 0.74 | 57 | empty |
| 2 | 425 | 0.56 | 0.74 | 58 | empty |
| 3 | 194 | 0.46 | 0.75 | 33 | empty |
| 4 | 190 | 0.46 | 0.75 | 32 | empty |
| 5 | 77 | 0.39 | 0.78 | 22 | empty |
Interfaces
12 interfaces between chains.
- H–L · 1805 Ų buried · 11 hydrogen bonds · protein-protein
- K–M · 1794 Ų buried · 12 hydrogen bonds · protein-protein
- B–M · 584 Ų buried · 15 hydrogen bonds · protein-protein
- H–P · 538 Ų buried · 5 hydrogen bonds · protein-protein
- A–H · 532 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1UWX · P1.2 serosubtype antigen derived from N. meningitidis PorA in complex with Fab fragment · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q54181
- Every structure of UniProt Q51220
- Elsewhere: RCSB PDB 1UWX · PDBe 1UWX · UniProt Q54181 · UniProt Q51220
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