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The crystal structure of the globular domain of sheep prion protein

Analyse The crystal structure of the globular domain of sheep prion protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1UW3
Type: protein
Length: 106 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prion protein
UniProt: P23907
Ligands: GSH, PO4

Structure

x-ray diffraction · 1 distinct chain · 59% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prion protein	protein	106	59% helix, 4% strand	P23907

Ligands and binding sites

GSH · Glutathione · ligand · chains A
PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 1 covalent, 1 disulfide (covalent ligand, disulfide).

Compared structures

1UW3 · The crystal structure of the globular domain of sheep prion protein · the same entry in another collection · chain A against A, TM-score 1.00
P23907 · AlphaFold monomer V2.0 prediction for major prion protein (P23907) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23907
Elsewhere: RCSB PDB 1UW3 · PDBe 1UW3 · UniProt P23907

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