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Probing the substrate specificity of the intracellular brain platelet- activating factor acetylhydrolase

Analyse Probing the substrate specificity of the intracellular brain platelet… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1BWR
Type: protein
Length: 212 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Platelet-activating factor acetylhydrolase
EC: 3.1.1.47
UniProt: Q29460
Pockets: 2 · best druggability 0.33

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Platelet-activating factor acetylhydrolase (EC 3.1.1.47)	protein	212	45% helix, 13% strand	Q29460

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.33	0.75	16	empty
2	52	0.28	0.75	12	empty

Compared structures

1BWR · Probing the substrate specificity of the intracellular brain platelet-activating factor… · the same entry in another collection · chain A against A, TM-score 1.00
Q29460 · AlphaFold monomer V2.0 prediction for platelet-activating factor acetylhydrolase ib… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q29460
Elsewhere: RCSB PDB 1BWR · PDBe 1BWR · UniProt Q29460

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