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Periplasmic domain of epsm from vibrio cholerae

Analyse Periplasmic domain of epsm from vibrio cholerae in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1UV7
Type: protein
Length: 150 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: General secretion pathway protein M
UniProt: P41851
Pockets: 1 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	General secretion pathway protein M	protein	76	34% helix, 41% strand	P41851
B	General secretion pathway protein M	protein	74	34% helix, 43% strand	P41851

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	183	0.56	0.79	27	empty

Interfaces

1 interface between chains.

A–B · 505 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

1UV7 · periplasmic domain of EpsM from Vibrio cholerae · the same entry in another collection · chain A against A, TM-score 1.00
P41851 · AlphaFold monomer V2.0 prediction for type II secretion system protein M (P41851) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41851
Elsewhere: RCSB PDB 1UV7 · PDBe 1UV7 · UniProt P41851

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