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Azurin mutant with met 121 replaced by gln

Analyse Azurin mutant with met 121 replaced by gln in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1URI
Type: protein
Length: 258 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Azurin
UniProt: P00280
Ligands: CU, SO4
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Azurin	protein	129	17% helix, 36% strand	P00280

Ligands and binding sites

CU · Copper (II) ion · metal · 2 copies · chains A, B
SO4 · Sulfate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.46	0.83	18	empty
2	70	0.44	0.81	20	empty

Interfaces

1 interface between chains.

A–B · 511 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1URI · Azurin mutant with met 121 replaced by gln · the same entry in another collection · chain A against A, TM-score 1.00
P00280 · AlphaFold monomer V2.0 prediction for azurin (P00280) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00280
Elsewhere: RCSB PDB 1URI · PDBe 1URI · UniProt P00280

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