Research workbench
Crystal structure of TT0143 from thermus thermophilus HB8
Analyse Crystal structure of TT0143 from thermus thermophilus HB8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ULU
- Type
- protein
- Length
- 995 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Enoyl-acyl carrier protein reductase
- EC
- 1.3.1.10
- UniProt
- Q5SLI9
- Pockets
- 8 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Enoyl-acyl carrier protein reductase (EC 1.3.1.10) | protein | 246 | 50% helix, 20% strand | Q5SLI9 |
| B | Enoyl-acyl carrier protein reductase (EC 1.3.1.10) | protein | 257 | 49% helix, 19% strand | Q5SLI9 |
| C | Enoyl-acyl carrier protein reductase (EC 1.3.1.10) | protein | 244 | 48% helix, 20% strand | Q5SLI9 |
| D | Enoyl-acyl carrier protein reductase (EC 1.3.1.10) | protein | 248 | 48% helix, 19% strand | Q5SLI9 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1004 | 0.86 | 0.87 | 56 | empty |
| 2 | 432 | 0.79 | 0.87 | 58 | empty |
| 3 | 649 | 0.70 | 0.78 | 66 | empty |
| 4 | 409 | 0.59 | 0.75 | 35 | empty |
| 5 | 136 | 0.53 | 0.80 | 21 | empty |
Interfaces
6 interfaces between chains.
- B–D · 1857 Ų buried · 38 hydrogen bonds · protein-protein
- A–C · 1853 Ų buried · 36 hydrogen bonds · protein-protein
- C–D · 1773 Ų buried · 28 hydrogen bonds · protein-protein
- A–B · 1753 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 710 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 26 modified (engineered).
Compared structures
- 1ULU · Crystal structure of tt0143 from Thermus thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SLI9
- Elsewhere: RCSB PDB 1ULU · PDBe 1ULU · UniProt Q5SLI9
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