Research workbench
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
Analyse A short peptide insertion crucial for angiostatic activity of human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ULH
- Type
- protein
- Length
- 743 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophanyl-tRNA synthetase
- EC
- 6.1.1.2
- UniProt
- P23381
- Pockets
- 8 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophanyl-tRNA synthetase (EC 6.1.1.2) | protein | 364 | 50% helix, 10% strand | P23381 |
| B | Tryptophanyl-tRNA synthetase (EC 6.1.1.2) | protein | 379 | 49% helix, 13% strand | P23381 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 368 | 0.78 | 0.88 | 40 | empty |
| 2 | 533 | 0.69 | 0.78 | 45 | empty |
| 3 | 235 | 0.53 | 0.76 | 30 | empty |
| 4 | 122 | 0.45 | 0.77 | 22 | empty |
| 5 | 126 | 0.40 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1564 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 1ULH · A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA… · the same entry in another collection · chain A against A, TM-score 1.00
- P23381 · AlphaFold monomer V2.0 prediction for tryptophan--tRNA ligase, cytoplasmic (P23381) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23381
- Elsewhere: RCSB PDB 1ULH · PDBe 1ULH · UniProt P23381
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