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Crystal structure of gamma-butyrolactone receptor (arpa like protein)

Analyse Crystal structure of gamma-butyrolactone receptor (arpa like protein) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1UI5
Type: protein
Length: 402 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: A-factor receptor homolog
UniProt: O66122
Pockets: 6 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	A-factor receptor homolog	protein	199	72% helix, 0% strand	O66122
B	A-factor receptor homolog	protein	203	74% helix, 0% strand	O66122

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	118	0.79	0.97	23	empty
2	177	0.74	0.90	29	empty
3	84	0.48	0.82	21	empty
4	61	0.41	0.81	14	empty
5	74	0.36	0.77	20	empty

Interfaces

1 interface between chains.

A–B · 1518 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified, 1 disulfide (engineered, disulfide).

Compared structures

1UI5 · Crystal structure of gamma-butyrolactone receptor (ArpA like protein) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O66122
Elsewhere: RCSB PDB 1UI5 · PDBe 1UI5 · UniProt O66122

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