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Crystal structure of uracil-DNA glycosylase from thermus thermophilus HB8

Analyse Crystal structure of uracil-DNA glycosylase from thermus thermophilus HB8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1UI1
Type: protein
Length: 188 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uracil-DNA glycosylase
EC: 3.2.2.-
UniProt: Q7WYV4
Ligands: SF4
Pockets: 2 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uracil-DNA glycosylase (EC 3.2.2.-)	protein	188	46% helix, 12% strand	Q7WYV4

Ligands and binding sites

SF4 · Iron/sulfur cluster · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	147	0.50	0.78	29	empty
2	68	0.36	0.77	13	empty

Modifications

Observed in the structure: 3 modified (engineered).

Compared structures

1UI1 · Crystal Structure Of Uracil-DNA Glycosylase From Thermus Thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7WYV4
Elsewhere: RCSB PDB 1UI1 · PDBe 1UI1 · UniProt Q7WYV4

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