Research workbench
Crystal structure of ligand-free human uridine-cytidine kinase 2
Analyse Crystal structure of ligand-free human uridine-cytidine kinase 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1UFQ
- Type
- protein
- Length
- 842 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uridine-cytidine kinase 2
- EC
- 2.7.1.48
- UniProt
- Q9BZX2
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 47% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Uridine-cytidine kinase 2 (EC 2.7.1.48) | protein | 212 | 47% helix, 18% strand | Q9BZX2 |
| B | Uridine-cytidine kinase 2 (EC 2.7.1.48) | protein | 208 | 46% helix, 22% strand | Q9BZX2 |
| D | Uridine-cytidine kinase 2 (EC 2.7.1.48) | protein | 210 | 48% helix, 21% strand | Q9BZX2 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1173 | 0.74 | 0.77 | 94 | empty |
| 2 | 270 | 0.53 | 0.76 | 31 | empty |
| 3 | 172 | 0.47 | 0.76 | 29 | empty |
| 4 | 172 | 0.45 | 0.75 | 35 | empty |
| 5 | 127 | 0.40 | 0.75 | 28 | empty |
Interfaces
6 interfaces between chains.
- A–D · 810 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 748 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 676 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 662 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 36 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1UFQ · Crystal structure of ligand-free human uridine-cytidine kinase 2 · the same entry in another collection · chain C against C, TM-score 1.00
- Q9BZX2 · AlphaFold monomer V2.0 prediction for uridine-cytidine kinase 2 (Q9BZX2) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BZX2
- Elsewhere: RCSB PDB 1UFQ · PDBe 1UFQ · UniProt Q9BZX2
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