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Nucleotide mimicry in the crystal structure of the uracil- DNA glycosylase-uracil glycosylase inhibitor protein complex

Analyse Nucleotide mimicry in the crystal structure of the uracil- DNA… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1UDI
Type: protein
Length: 310 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uracil-DNA glycosylase; Uracil-DNA glycosylase inhibitor protein
EC: 3.2.2.3
UniProt: P10186, P14739
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E	Uracil-DNA glycosylase (EC 3.2.2.3)	protein	227	39% helix, 11% strand	P10186
I	Uracil-DNA glycosylase inhibitor protein	protein	83	22% helix, 40% strand	P14739

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.71	0.98	22	empty
2	78	0.46	0.82	17	empty
3	101	0.39	0.76	16	empty
4	81	0.31	0.73	20	empty

Interfaces

1 interface between chains.

E–I · 1052 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

1UDI · Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil… · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10186
Every structure of UniProt P14739
Elsewhere: RCSB PDB 1UDI · PDBe 1UDI · UniProt P10186 · UniProt P14739

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