Research workbench
Crystal structure of the broadly neutralizing anti-HIV Fab F105
Analyse Crystal structure of the broadly neutralizing anti-HIV Fab F105 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1U6A
- Type
- protein
- Length
- 436 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F105 light chain; F105 heavy chain
- UniProt
- Q6N089
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | F105 light chain | protein | 214 | 7% helix, 57% strand | — |
| H | F105 heavy chain | protein | 222 | 9% helix, 50% strand | Q6N089 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 609 | 0.63 | 0.74 | 69 | empty |
| 2 | 52 | 0.28 | 0.74 | 16 | empty |
| 3 | 55 | 0.25 | 0.72 | 14 | empty |
Interfaces
1 interface between chains.
- L–H · 1923 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1U6A · Crystal Structure of the Broadly Neutralizing Anti-HIV Fab F105 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6N089
- Elsewhere: RCSB PDB 1U6A · PDBe 1U6A · UniProt Q6N089
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.