Research workbench
Crystal structure of human alcohol dehydrogenase gamma-2-gamma-2 isoform complexed with N-1-methylheptylformamide determined to 1.45 ångström resolution
Analyse Crystal structure of human alcohol dehydrogenase gamma-2-gamma-2 isoform… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1U3W
- Type
- protein
- Length
- 748 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alcohol dehydrogenase gamma chain
- EC
- 1.1.1.1
- UniProt
- P00326
- Ligands
- NAD, FXY, ZN
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Alcohol dehydrogenase gamma chain (EC 1.1.1.1) | protein | 374 | 30% helix, 26% strand | P00326 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 2 copies · chains A, B
- FXY · 1-methylheptylformamide · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 493 | 0.77 | 0.84 | 63 | NAD, FXY |
| 2 | 507 | 0.77 | 0.84 | 68 | NAD, FXY |
| 3 | 501 | 0.71 | 0.81 | 67 | empty |
Interfaces
1 interface between chains.
- A–B · 1752 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 1U3W · Crystal Structure of Human Alcohol Dehydrogenase Gamma-2-Gamma-2 Isoform Complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- P00326 · AlphaFold monomer V2.0 prediction for alcohol dehydrogenase 1C (P00326) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00326
- Elsewhere: RCSB PDB 1U3W · PDBe 1U3W · UniProt P00326
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