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Triglycine variant of the arno pleckstrin homology domain in complex with INS(1,3,4,5)P4

Analyse Triglycine variant of the arno pleckstrin homology domain in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1U27
Type: protein
Length: 119 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytohesin 2
UniProt: P63034
Ligands: 4IP
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytohesin 2	protein	119	13% helix, 38% strand	P63034

Ligands and binding sites

4IP · Inositol-(1,3,4,5)-tetrakisphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.37	0.76	21	4IP

Compared structures

1U27 · Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,3,4,5)P4 · the same entry in another collection · chain A against A, TM-score 1.00
P63034 · AlphaFold monomer V2.0 prediction for cytohesin-2 (P63034) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63034
Elsewhere: RCSB PDB 1U27 · PDBe 1U27 · UniProt P63034

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