Research workbench

Signal transduction adaptor growth factor, GRB2 SH2 domain complexed with phosphotyrosyl heptapeptide lys-pro-phe-ptyr-val-asn-val-NH2 (kfppyvnc-NH2)

Analyse Signal transduction adaptor growth factor, GRB2 SH2 domain complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1TZE
Type: protein
Length: 105 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Growth factor receptor-bound protein 2; Phosphotyrosyl heptapeptide…
UniProt: P29354
Ligands: NH2

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E	Growth factor receptor-bound protein 2	protein	98	16% helix, 28% strand	P29354
I	Phosphotyrosyl heptapeptide lys-pro-phe-ptyr-val-asn-val- NH2	protein	7	0% helix, 0% strand	—

Ligands and binding sites

NH2 · Amino group · ion · chains I

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

E–I · 452 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

1TZE · Signal transduction adaptor growth factor, GRB2 SH2 domain complexed with phosphotyrosyl… · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29354
Elsewhere: RCSB PDB 1TZE · PDBe 1TZE · UniProt P29354

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.