Research workbench
PH domain and btk motif from BRUTON'S tyrosine kinase mutant R28C
Analyse PH domain and btk motif from BRUTON'S tyrosine kinase mutant R28C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1BTK
- Type
- protein
- Length
- 329 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BRUTON'S tyrosine kinase
- EC
- 2.7.1.112
- UniProt
- Q06187
- Ligands
- ZN, NA
- Pockets
- 5 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BRUTON'S tyrosine kinase (EC 2.7.1.112) | protein | 160 | 16% helix, 38% strand | Q06187 |
| B | BRUTON'S tyrosine kinase (EC 2.7.1.112) | protein | 169 | 15% helix, 36% strand | Q06187 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 69 | 0.42 | 0.81 | 20 | empty |
| 2 | 74 | 0.42 | 0.80 | 20 | empty |
| 3 | 137 | 0.41 | 0.75 | 29 | empty |
| 4 | 61 | 0.41 | 0.81 | 19 | empty |
| 5 | 57 | 0.29 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1087 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 1BTK · PH domain and btk motif from BRUTON'S tyrosine kinase mutant R28C · the same entry in another collection · chain A against A, TM-score 1.00
- Q06187 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase btk (Q06187) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06187
- Elsewhere: RCSB PDB 1BTK · PDBe 1BTK · UniProt Q06187
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.