Research workbench
Crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside
Analyse Crystal structure of aminoimidazole riboside kinase complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TZ3
- Type
- protein
- Length
- 597 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative sugar kinase
- EC
- 2.7.1.4
- UniProt
- Q8ZKR2
- Ligands
- AIS, K
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative sugar kinase (EC 2.7.1.4) | protein | 299 | 38% helix, 22% strand | Q8ZKR2 |
| B | Putative sugar kinase (EC 2.7.1.4) | protein | 298 | 39% helix, 21% strand | Q8ZKR2 |
Ligands and binding sites
- AIS · 5-aminoimidazole ribonucleoside · ligand · chains A
- K · Potassium ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 505 | 0.70 | 0.80 | 71 | empty |
| 2 | 522 | 0.69 | 0.79 | 76 | AIS |
Interfaces
1 interface between chains.
- A–B · 817 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 1TZ3 · crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside · the same entry in another collection · chain A against A, TM-score 1.00
- Q8ZKR2 · AlphaFold monomer V2.0 prediction for aminoimidazole riboside kinase (Q8ZKR2) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8ZKR2
- Elsewhere: RCSB PDB 1TZ3 · PDBe 1TZ3 · UniProt Q8ZKR2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.