Research workbench
Crystal structure of transcriptional activator tena from bacillus subtilis
Analyse Crystal structure of transcriptional activator tena from bacillus subtilis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TYH
- Type
- protein
- Length
- 884 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional activator tena
- UniProt
- P25052
- Pockets
- 11 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, E | Transcriptional activator tena | protein | 221 | 78% helix, 0% strand | P25052 |
Pockets
11 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 816 | 0.76 | 0.80 | 78 | empty |
| 2 | 78 | 0.75 | 0.97 | 16 | empty |
| 3 | 1129 | 0.74 | 0.77 | 92 | empty |
| 4 | 332 | 0.74 | 0.85 | 44 | empty |
| 5 | 225 | 0.73 | 0.88 | 39 | empty |
Interfaces
6 interfaces between chains.
- A–D · 1098 Ų buried · 19 hydrogen bonds · protein-protein
- B–E · 1094 Ų buried · 19 hydrogen bonds · protein-protein
- B–D · 952 Ų buried · 6 hydrogen bonds · protein-protein
- A–E · 945 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 156 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 modified (engineered).
Compared structures
- 1TYH · Crystal Structure of Transcriptional Activator tenA from Bacillus subtilis · the same entry in another collection · chain A against A, TM-score 1.00
- P25052 · AlphaFold monomer V2.0 prediction for aminopyrimidine aminohydrolase (P25052) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25052
- Elsewhere: RCSB PDB 1TYH · PDBe 1TYH · UniProt P25052
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