Research workbench
The X-ray crystal structure refinements of normal human transthyretin and the amyloidogenic VAL30MET variant to 1.7 ångströms resolution
Analyse The X-ray crystal structure refinements of normal human transthyretin and the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TTC
- Type
- protein
- Length
- 254 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transthyretin
- UniProt
- P02766
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transthyretin | protein | 127 | 5% helix, 48% strand | P02766 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.34 | 0.76 | 16 | empty |
| 2 | 57 | 0.27 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 939 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 1TTC · The X-ray crystal structure refinements of normal human transthyretin and the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02766
- Elsewhere: RCSB PDB 1TTC · PDBe 1TTC · UniProt P02766
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