Research workbench

Q139K mutant of toxic shock syndrome toxin-1 from S. aureus

Analyse Q139K mutant of toxic shock syndrome toxin-1 from S. aureus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1TS4
Type: protein
Length: 388 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Toxic shock syndrome toxin-1
UniProt: P06886
Pockets: 3 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Toxic shock syndrome toxin-1	protein	194	15% helix, 45% strand	P06886

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.38	0.80	13	empty
2	64	0.36	0.78	14	empty
3	89	0.35	0.74	25	empty

Interfaces

1 interface between chains.

A–B · 498 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1TS4 · Q139K mutant of toxic shock syndrome toxin-1 from S. aureus · the same entry in another collection · chain A against A, TM-score 1.00
P06886 · AlphaFold monomer V2.0 prediction for toxic shock syndrome toxin-1 (P06886) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06886
Elsewhere: RCSB PDB 1TS4 · PDBe 1TS4 · UniProt P06886

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