Research workbench
The structure of triosephosphate isomerase from escherichia COLI determined at 2.6 ångström resolution
Analyse The structure of triosephosphate isomerase from escherichia COLI determined at… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TRE
- Type
- protein
- Length
- 508 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Triosephosphate isomerase
- EC
- 5.3.1.1
- UniProt
- P0A858
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Triosephosphate isomerase (EC 5.3.1.1) | protein | 255 | 49% helix, 15% strand | P0A858 |
| B | Triosephosphate isomerase (EC 5.3.1.1) | protein | 253 | 47% helix, 15% strand | P0A858 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 307 | 0.69 | 0.84 | 46 | empty |
| 2 | 141 | 0.45 | 0.76 | 31 | empty |
| 3 | 103 | 0.44 | 0.78 | 21 | empty |
| 4 | 51 | 0.36 | 0.80 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1710 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 1TRE · The structure of triosephosphate isomerase from escherichia COLI determined at 2.6… · the same entry in another collection · chain A against A, TM-score 1.00
- P0A858 · AlphaFold monomer V2.0 prediction for triosephosphate isomerase (P0A858) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A858
- Elsewhere: RCSB PDB 1TRE · PDBe 1TRE · UniProt P0A858
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