Research workbench
Thermostable thymidylate synthase a from bacillus subtilis
Analyse Thermostable thymidylate synthase a from bacillus subtilis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1BSF
- Type
- protein
- Length
- 556 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thymidylate synthase a
- EC
- 2.1.1.45
- UniProt
- P42326
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Thymidylate synthase a (EC 2.1.1.45) | protein | 278 | 33% helix, 23% strand | P42326 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 752 | 0.72 | 0.78 | 67 | empty |
| 2 | 805 | 0.72 | 0.77 | 66 | empty |
| 3 | 73 | 0.60 | 0.90 | 19 | empty |
| 4 | 58 | 0.59 | 0.91 | 16 | empty |
| 5 | 50 | 0.29 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 2319 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 1BSF · Thermostable thymidylate synthase a from bacillus subtilis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42326
- Elsewhere: RCSB PDB 1BSF · PDBe 1BSF · UniProt P42326
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