Research workbench

Crystal structure of T161S duck delta 2 crystallin mutant

Analyse Crystal structure of T161S duck delta 2 crystallin mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1TJU
Type: protein
Length: 1,797 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Delta crystallin II
EC: 4.3.2.1
UniProt: P24058
Pockets: 20 · best druggability 0.79

Structure

x-ray diffraction · 3 distinct chains · 68% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Delta crystallin II (EC 4.3.2.1)	protein	448	67% helix, 7% strand	P24058
B, C	Delta crystallin II (EC 4.3.2.1)	protein	450	68% helix, 7% strand	P24058
D	Delta crystallin II (EC 4.3.2.1)	protein	449	68% helix, 5% strand	P24058

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	887	0.79	0.82	77	empty
2	1066	0.77	0.79	89	empty
3	79	0.77	0.99	18	empty
4	77	0.76	0.99	18	empty
5	775	0.75	0.80	63	empty

Interfaces

6 interfaces between chains.

B–D · 3847 Å² buried · 64 hydrogen bonds · protein-protein
A–C · 3797 Å² buried · 65 hydrogen bonds · protein-protein
B–C · 1865 Å² buried · 21 hydrogen bonds · protein-protein
A–B · 1825 Å² buried · 19 hydrogen bonds · protein-protein
A–D · 1821 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

1TJU · Crystal Structure of T161S Duck Delta 2 Crystallin Mutant · the same entry in another collection · chain D against D, TM-score 1.00
P24058 · AlphaFold monomer V2.0 prediction for argininosuccinate lyase (P24058) · a predicted model of the same protein · chain D against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P24058
Elsewhere: RCSB PDB 1TJU · PDBe 1TJU · UniProt P24058

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.