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Crystal structure of nmra, a negative transcriptional regulator, in complex with NADP at 1.7A resolution

Analyse Crystal structure of nmra, a negative transcriptional regulator, in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1TI7
Type: protein
Length: 324 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nitrogen metabolite repression regulator nmra
UniProt: O59919
Ligands: NAP, K, CL
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nitrogen metabolite repression regulator nmra	protein	324	40% helix, 18% strand	O59919

Ligands and binding sites

NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
K · Potassium ion · metal · 5 copies · chains A
CL · Chloride ion · ion · 8 copies · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	633	0.74	0.80	59	K, CL, NAP
2	53	0.31	0.76	14	CL

Compared structures

1TI7 · Crystal structure of nmra, a negative transcriptional regulator, in complex with NADP at… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt O59919
Elsewhere: RCSB PDB 1TI7 · PDBe 1TI7 · UniProt O59919

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