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Crystal structure of an archaeal sm protein from sulfolobus solfataricus

Analyse Crystal structure of an archaeal sm protein from sulfolobus solfataricus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1TH7
Type
protein
Length
1,092 residues
Chains
14
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Small nuclear riboprotein protein
UniProt
Q97ZQ0
Pockets
20 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 51% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, B, C, D, E, F, G, H, I, J, K, L, M, NSmall nuclear riboprotein proteinprotein7817% helix, 51% strandQ97ZQ0

Pockets

20 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
18530.700.7685empty
22530.530.7629empty
32310.500.7530empty
41980.480.7525empty
5630.470.8318empty

Interfaces

30 interfaces between chains.

  • D–E · 937 Ų buried · 13 hydrogen bonds · protein-protein
  • F–G · 925 Ų buried · 10 hydrogen bonds · protein-protein
  • M–N · 887 Ų buried · 13 hydrogen bonds · protein-protein
  • B–C · 884 Ų buried · 14 hydrogen bonds · protein-protein
  • A–G · 880 Ų buried · 11 hydrogen bonds · protein-protein

Compared structures

  • 1TH7 · Crystal Structure of an Archaeal Sm Protein from Sulfolobus solfataricus · the same entry in another collection · chain A against A, TM-score 1.00

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