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Crystal structure of mini-igf-1(2)
Analyse Crystal structure of mini-igf-1(2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TGR
- Type
- protein
- Length
- 104 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor ia
- UniProt
- P01343
- Pockets
- 3 · best druggability 0.45
Structure
x-ray diffraction · 1 distinct chain · 69% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Insulin-like growth factor ia | protein | 52 | 69% helix, 8% strand | P01343 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 176 | 0.45 | 0.74 | 27 | empty |
| 2 | 70 | 0.39 | 0.79 | 15 | empty |
| 3 | 87 | 0.37 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 465 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1TGR · Crystal Structure of mini-IGF-1(2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01343
- Elsewhere: RCSB PDB 1TGR · PDBe 1TGR · UniProt P01343
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