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Extracellular domain of human tissue factor

Analyse Extracellular domain of human tissue factor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1TFH
Type: protein
Length: 384 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human tissue factor
UniProt: P13726

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Human tissue factor	protein	202	8% helix, 50% strand	P13726
B	Human tissue factor	protein	182	7% helix, 45% strand	P13726

Interfaces

1 interface between chains.

A–B · 11 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1TFH · Extracellular domain of human tissue factor · the same entry in another collection · chain A against A, TM-score 1.00
P13726 · AlphaFold monomer V2.0 prediction for tissue factor (P13726) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13726
Elsewhere: RCSB PDB 1TFH · PDBe 1TFH · UniProt P13726

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