Research workbench
Murine T-cell antigen receptor 2C clone
Analyse Murine T-cell antigen receptor 2C clone in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TCR
- Type
- protein
- Length
- 439 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha, beta T-cell receptor (VB8.2DB2JB2.4CB2\
- Ligands
- NAG, FUC, BMA, SO4
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha, beta T-cell receptor (VB8.2DB2JB2.4CB2\ | protein | 202 | 3% helix, 44% strand | — |
| B | Alpha, beta T-cell receptor (VB8.2DB2JB2.4CB2\ | protein | 237 | 7% helix, 51% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 7 copies · chains A, B
- FUC · alpha-L-fucopyranose · sugar · 2 copies · chains B
- BMA · beta-D-mannopyranose · sugar
- SO4 · Sulfate ion · ion · 3 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1060 | 0.73 | 0.76 | 82 | empty |
| 2 | 210 | 0.51 | 0.77 | 44 | empty |
| 3 | 114 | 0.44 | 0.78 | 24 | empty |
| 4 | 89 | 0.40 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2221 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 glycan, 3 disulfide (N-glycosylation, disulfide).
Compared structures
- 1TCR · Murine T-cell antigen receptor 2C clone · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1TCR · PDBe 1TCR
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