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Transposase TC3A1-65 from caenorhabditis elegans

Analyse Transposase TC3A1-65 from caenorhabditis elegans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1TC3
Type
protein + DNA
Length
92 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA (5'- D(*AP*GP*GP*GP*GP*GP*GP*GP*TP*CP*CP*TP*AP*TP*AP*GP*A P*AP*CP*TP*T)-3'); DNA (5'…
UniProt
P34257
Pockets
2 · best druggability 0.50

Structure

x-ray diffraction · 3 distinct chains · 57% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA (5'- D(*AP*GP*GP*GP*GP*GP*GP*GP*TP*CP*CP*TP*AP*TP*AP*GP*A P*AP*CP*TP*T)-3')dna21——
BDNA (5'- D(*AP*GP*TP*TP*CP*TP*AP*TP*AP*GP*GP*AP*CP*CP*CP*CP*C P*CP*CP*T)-3')dna20——
CProtein (TC3 transposase)protein5157% helix, 0% strandP34257

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12170.500.7622empty
21720.410.7324empty

Interfaces

3 interfaces between chains.

  • A–B · 894 Ų buried · 100 hydrogen bonds · nucleic-nucleic
  • A–C · 591 Ų buried · 21 hydrogen bonds · protein-nucleic
  • B–C · 518 Ų buried · 13 hydrogen bonds · protein-nucleic

Compared structures

  • 1TC3 · Transposase TC3A1-65 from caenorhabditis elegans · the same entry in another collection · chain A against A, TM-score 1.00
  • P34257 · AlphaFold monomer V2.0 prediction for transposable element TC3 transposase (P34257) · a predicted model of the same protein · chain C against A, TM-score 0.93

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