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Human tissue inhibitor of metalloproteinase-2

Analyse Human tissue inhibitor of metalloproteinase-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1BR9
Type: protein
Length: 182 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metalloproteinase-2 inhibitor
UniProt: P16035
Pockets: 1 · best druggability 0.41

Structure

x-ray diffraction · 1 distinct chain · 18% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Metalloproteinase-2 inhibitor	protein	182	18% helix, 38% strand	P16035

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	108	0.41	0.76	20	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

1BR9 · Human tissue inhibitor of metalloproteinase-2 · the same entry in another collection · chain A against A, TM-score 1.00
P16035 · AlphaFold monomer V2.0 prediction for metalloproteinase inhibitor 2 (P16035) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16035
Elsewhere: RCSB PDB 1BR9 · PDBe 1BR9 · UniProt P16035

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