Research workbench
Crystal structure of the M564G mutant of murine carnitine acetyltransferase in complex with carnitine
Analyse Crystal structure of the M564G mutant of murine carnitine acetyltransferase in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1T7O
- Type
- protein
- Length
- 599 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carnitine acetyltransferase
- EC
- 2.3.1.7
- UniProt
- P47934
- Ligands
- 152
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carnitine acetyltransferase (EC 2.3.1.7) | protein | 599 | 45% helix, 15% strand | P47934 |
Ligands and binding sites
- 152 · Carnitine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 895 | 0.77 | 0.80 | 79 | 152 |
| 2 | 204 | 0.57 | 0.80 | 27 | empty |
| 3 | 126 | 0.50 | 0.80 | 20 | empty |
| 4 | 78 | 0.47 | 0.82 | 16 | empty |
| 5 | 57 | 0.32 | 0.77 | 13 | empty |
Compared structures
- 1T7O · Crystal structure of the M564G mutant of murine carnitine acetyltransferase in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- P47934 · AlphaFold monomer V2.0 prediction for carnitine O-acetyltransferase (P47934) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47934
- Elsewhere: RCSB PDB 1T7O · PDBe 1T7O · UniProt P47934
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.