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X-ray structure of [lys(-2)-arg(-1)-DES(17-21)]-endothelin-1 peptide

Analyse X-ray structure of [lys(-2)-arg(-1)-DES(17-21)]-endothelin-1 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1T7H
Type: protein
Length: 36 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endothelin-1
UniProt: P05305

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Endothelin-1	protein	18	39% helix, 17% strand	P05305

Interfaces

1 interface between chains.

A–B · 415 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1T7H · X-ray structure of [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide · the same entry in another collection · chain A against A, TM-score 1.00
P05305 · AlphaFold monomer V2.0 prediction for endothelin-1 (P05305) · a predicted model of the same protein · chain B against A, TM-score 0.52

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05305
Elsewhere: RCSB PDB 1T7H · PDBe 1T7H · UniProt P05305

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