Research workbench
Crystal structure of the translation initiation factor eif-2B, subunit delta, from a. fulgidus
Analyse Crystal structure of the translation initiation factor eif-2B, subunit delta… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1T5O
- Type
- protein
- Length
- 1,360 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor EIF2B, subunit delta
- UniProt
- O29877
- Pockets
- 8 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Translation initiation factor EIF2B, subunit delta | protein | 340 | 44% helix, 18% strand | O29877 |
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1001 | 0.80 | 0.82 | 81 | empty |
| 2 | 884 | 0.77 | 0.80 | 80 | empty |
| 3 | 801 | 0.76 | 0.81 | 76 | empty |
| 4 | 841 | 0.75 | 0.79 | 79 | empty |
| 5 | 875 | 0.75 | 0.79 | 80 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2304 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 2231 Ų buried · 22 hydrogen bonds · protein-protein
- A–D · 579 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 520 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 20 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1T5O · Crystal structure of the translation initiation factor eIF-2B, subunit delta, from A.… · the same entry in another collection · chain A against A, TM-score 1.00
- O29877 · AlphaFold monomer V2.0 prediction for putative methylthioribose-1-phosphate isomerase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O29877
- Elsewhere: RCSB PDB 1T5O · PDBe 1T5O · UniProt O29877
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