Research workbench
Crystal structure of the DNA repair protein uvrb point mutant Y96A revealing a novel fold for domain 2
Analyse Crystal structure of the DNA repair protein uvrb point mutant Y96A revealing a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1T5L
- Type
- protein
- Length
- 1,190 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uvrabc system protein B
- UniProt
- P56981
- Ligands
- ZN
- Pockets
- 13 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Uvrabc system protein B | protein | 595 | 43% helix, 17% strand | P56981 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 646 | 0.76 | 0.82 | 48 | empty |
| 2 | 640 | 0.76 | 0.82 | 55 | empty |
| 3 | 853 | 0.74 | 0.78 | 91 | empty |
| 4 | 773 | 0.73 | 0.78 | 72 | empty |
| 5 | 85 | 0.66 | 0.92 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 11 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1T5L · Crystal structure of the DNA repair protein UvrB point mutant Y96A revealing a novel fold… · the same entry in another collection · chain A against A, TM-score 1.00
- P56981 · AlphaFold monomer V2.0 prediction for uvrabc system protein B (P56981) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P56981
- Elsewhere: RCSB PDB 1T5L · PDBe 1T5L · UniProt P56981
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