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Solution structure of double-stranded RNA binding domain of S. cerevisiae RNase III (RNT1P) in complex with the 5' terminal RNA hairpin of SNR47 precursor

Analyse Solution structure of double-stranded RNA binding domain of S. cerevisiae RNase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1T4L
Type: protein + RNA
Length: 122 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5' terminal hairpin of SNR47 precursor; Ribonuclease III
UniProt: Q02555
Pockets: 2 · best druggability 0.60

Structure

solution nmr · 2 distinct chains · 40% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5' terminal hairpin of SNR47 precursor	rna	32	—	—
B	Ribonuclease III	protein	90	40% helix, 22% strand	Q02555

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	387	0.60	0.76	36	empty
2	50	0.28	0.76	12	empty

Interfaces

1 interface between chains.

A–B · 788 Å² buried · 14 hydrogen bonds · protein-nucleic

Compared structures

1T4L · Solution structure of double-stranded RNA binding domain of S. cerevisiae RNase III… · the same entry in another collection · chain A against A, TM-score 1.00
Q02555 · AlphaFold monomer V2.0 prediction for ribonuclease 3 (Q02555) · a predicted model of the same protein · chain B against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02555
Elsewhere: RCSB PDB 1T4L · PDBe 1T4L · UniProt Q02555

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