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Structure of SLR0077/SUFS, the essential cysteine desulfurase from synechocystis pcc 6803
Analyse Structure of SLR0077/SUFS, the essential cysteine desulfurase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1T3I
- Type
- protein
- Length
- 811 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable cysteine desulfurase
- EC
- 2.8.1.7
- UniProt
- Q55793
- Ligands
- PLP, TU4, FRU
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable cysteine desulfurase (EC 2.8.1.7) | protein | 406 | 45% helix, 18% strand | Q55793 |
| B | Probable cysteine desulfurase (EC 2.8.1.7) | protein | 405 | 44% helix, 18% strand | Q55793 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B
- TU4 · 3-O-octanoyl-alpha-D-glucopyranose · ligand · chains A
- FRU · beta-D-fructofuranose · sugar · chains A
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 354 | 0.70 | 0.83 | 57 | PLP, GOL |
| 2 | 293 | 0.67 | 0.83 | 51 | PLP, GOL |
| 3 | 51 | 0.49 | 0.86 | 12 | TU4 |
| 4 | 150 | 0.42 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 3506 Ų buried · 64 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 1T3I · Structure of slr0077/SufS, the Essential Cysteine Desulfurase from Synechocystis PCC 6803 · the same entry in another collection · chain A against A, TM-score 1.00
- Q55793 · AlphaFold monomer V2.0 prediction for probable cysteine desulfurase (Q55793) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q55793
- Elsewhere: RCSB PDB 1T3I · PDBe 1T3I · UniProt Q55793
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