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Three dimensional structure of a humanized anti-ifn-gamma Fab (huzaf) in P21 21 21 space group

Analyse Three dimensional structure of a humanized anti-ifn-gamma Fab (huzaf) in P21 21… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1T3F
Type: protein
Length: 434 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Huzaf antibody light chain; Huzaf antibody heavy chain
UniProt: Q6GMW1
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Huzaf antibody light chain	protein	214	5% helix, 50% strand	Q6GMW1
B	Huzaf antibody heavy chain	protein	220	10% helix, 50% strand	—

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	233	0.62	0.81	43	empty
2	327	0.53	0.74	44	empty
3	68	0.31	0.75	20	empty
4	51	0.25	0.73	16	empty

Interfaces

1 interface between chains.

A–B · 1941 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide, 1 modified (disulfide, cyclization).

Compared structures

1T3F · THREE DIMENSIONAL STRUCTURE OF A HUMANIZED ANTI-IFN-GAMMA FAB (HuZAF) IN P21 21 21 SPACE… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6GMW1
Elsewhere: RCSB PDB 1T3F · PDBe 1T3F · UniProt Q6GMW1

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