Research workbench

Structural insights and functional implications of choline acetyltransferase

Analyse Structural insights and functional implications of choline acetyltransferase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1T1U
Type: protein
Length: 597 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Choline O-acetyltransferase
EC: 2.3.1.6
UniProt: P32738
Pockets: 10 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Choline O-acetyltransferase (EC 2.3.1.6)	protein	597	45% helix, 15% strand	P32738

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	825	0.78	0.81	81	empty
2	66	0.53	0.87	24	empty
3	79	0.48	0.82	19	empty
4	75	0.41	0.79	17	empty
5	51	0.37	0.80	13	empty

Compared structures

1T1U · Structural Insights and Functional Implications of Choline Acetyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
P32738 · AlphaFold monomer V2.0 prediction for choline O-acetyltransferase (P32738) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32738
Elsewhere: RCSB PDB 1T1U · PDBe 1T1U · UniProt P32738

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