Research workbench

Trigger factor

Analyse Trigger factor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1T11
Type: protein
Length: 750 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trigger factor
UniProt: Q9KQS5
Pockets: 9 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Trigger factor	protein	376	41% helix, 20% strand	Q9KQS5
B	Trigger factor	protein	374	41% helix, 22% strand	Q9KQS5

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	628	0.68	0.77	47	empty
2	706	0.66	0.75	63	empty
3	546	0.65	0.76	45	empty
4	572	0.64	0.75	50	empty
5	282	0.56	0.77	24	empty

Interfaces

1 interface between chains.

A–B · 1918 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

1T11 · Trigger Factor · the same entry in another collection · chain A against A, TM-score 1.00
Q9KQS5 · AlphaFold monomer V2.0 prediction for trigger factor (Q9KQS5) · a predicted model of the same protein · chain B against A, TM-score 0.40

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9KQS5
Elsewhere: RCSB PDB 1T11 · PDBe 1T11 · UniProt Q9KQS5

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