Research workbench
Structure of an excitatory insect-specific toxin with an analgesic effect on mammalian from scorpion buthus martensii karsch
Analyse Structure of an excitatory insect-specific toxin with an analgesic effect on… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1T0Z
- Type
- protein
- Length
- 144 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insect neurotoxin
- UniProt
- O77091
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.37
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Insect neurotoxin | protein | 72 | 28% helix, 29% strand | O77091 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 11 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.37 | 0.75 | 20 | empty |
| 2 | 79 | 0.35 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 286 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1T0Z · Structure of an Excitatory Insect-specific Toxin with an Analgesic Effect on Mammalian… · the same entry in another collection · chain A against A, TM-score 1.00
- O77091 · AlphaFold monomer V2.0 prediction for beta-insect excitatory toxin bmk it-ap (O77091) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O77091
- Elsewhere: RCSB PDB 1T0Z · PDBe 1T0Z · UniProt O77091
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.