Research workbench

A198G:L230A flavocytochrome B2 with sulfite bound

Analyse A198G:L230A flavocytochrome B2 with sulfite bound in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SZG
Type: protein
Length: 777 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome B2, mitochondrial
EC: 1.1.2.3
UniProt: P00175
Ligands: FNS
Pockets: 12 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome B2, mitochondrial (EC 1.1.2.3)	protein	391	41% helix, 12% strand	P00175
B	Cytochrome B2, mitochondrial (EC 1.1.2.3)	protein	386	44% helix, 12% strand	P00175

Ligands and binding sites

FNS · N-sulfo-flavin mononucleotide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	246	0.72	0.87	38	FNS
2	238	0.71	0.87	43	FNS
3	71	0.55	0.87	13	empty
4	69	0.48	0.83	13	empty
5	103	0.47	0.80	20	empty

Interfaces

1 interface between chains.

A–B · 2641 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

1SZG · A198G:L230A flavocytochrome b2 with sulfite bound · the same entry in another collection · chain A against A, TM-score 1.00
P00175 · AlphaFold monomer V2.0 prediction for cytochrome B2, mitochondrial (P00175) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00175
Elsewhere: RCSB PDB 1SZG · PDBe 1SZG · UniProt P00175

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