Research workbench
GCN4-leucine zipper core mutant as N16A complexed with benzene
Analyse GCN4-leucine zipper core mutant as N16A complexed with benzene in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SWI
- Type
- protein
- Length
- 91 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GCN4P1
- UniProt
- P03069
- Ligands
- BNZ
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 89% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GCN4P1 | protein | 31 | 87% helix, 0% strand | P03069 |
| B, C | GCN4P1 | protein | 30 | 90% helix, 0% strand | P03069 |
Ligands and binding sites
- BNZ · Benzene · ligand · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.67 | 0.96 | 12 | BNZ |
Interfaces
3 interfaces between chains.
- A–B · 672 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 640 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 574 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1SWI · GCN4-leucine zipper core mutant as N16A complexed with benzene · the same entry in another collection · chain A against A, TM-score 1.00
- P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain C against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03069
- Elsewhere: RCSB PDB 1SWI · PDBe 1SWI · UniProt P03069
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