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Structure of SV40 large T antigen helicase domain

Analyse Structure of SV40 large T antigen helicase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SVO
Type: protein
Length: 724 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Large T antigen
UniProt: P03070
Ligands: ZN
Pockets: 9 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Large T antigen	protein	362	54% helix, 10% strand	P03070

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1001	0.82	0.83	78	empty
2	76	0.68	0.93	15	empty
3	108	0.63	0.87	15	empty
4	197	0.56	0.79	25	empty
5	161	0.53	0.79	24	empty

Interfaces

1 interface between chains.

A–B · 1340 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1SVO · Structure of SV40 large T antigen helicase domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03070
Elsewhere: RCSB PDB 1SVO · PDBe 1SVO · UniProt P03070

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