Sulfite oxidase from chicken liver

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 32% strand (DSSP).

Ligands and binding sites

• MTE · Phosphonic acidmono-(2-amino-5,6-dimercapto-4-oxo-3,7,8A,9,10,10A-hexahydro-4H-8-oxa-1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester · ligand · 2 copies · chains A, B
• HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
• MO · Molybdenum atom · metal · 2 copies · chains A, B
• SO4 · Sulfate ion · ion · 4 copies · chains A, B
• GOL · Glycerol · additive · chains A
• EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1450 Ų buried · 25 hydrogen bonds · protein-protein

Compared structures

• 1SOX · Sulfite oxidase from chicken liver · the same entry in another collection · chain A against A, TM-score 1.00
• P07850 · AlphaFold monomer V2.0 prediction for sulfite oxidase (P07850) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P07850
• Elsewhere: RCSB PDB 1SOX · PDBe 1SOX · UniProt P07850