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Crystal structure of the degs stress sensor

Analyse Crystal structure of the degs stress sensor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SOT
Type: protein
Length: 858 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protease degs
EC: 3.4.21.-
UniProt: P31137
Pockets: 8 · best druggability 0.67

Structure

x-ray diffraction · 3 distinct chains · 14% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protease degs (EC 3.4.21.-)	protein	283	14% helix, 34% strand	P31137
B	Protease degs (EC 3.4.21.-)	protein	294	15% helix, 35% strand	P31137
C	Protease degs (EC 3.4.21.-)	protein	281	14% helix, 28% strand	P31137

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	420	0.67	0.80	65	empty
2	81	0.56	0.86	23	empty
3	116	0.55	0.83	36	empty
4	132	0.54	0.81	35	empty
5	111	0.41	0.76	20	empty

Interfaces

3 interfaces between chains.

A–B · 846 Å² buried · 11 hydrogen bonds · protein-protein
A–C · 796 Å² buried · 9 hydrogen bonds · protein-protein
B–C · 776 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 modified (engineered).

Compared structures

1SOT · Crystal Structure of the DegS stress sensor · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31137
Elsewhere: RCSB PDB 1SOT · PDBe 1SOT · UniProt P31137

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