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Structure of the human cytosolic sialidase NEU2

Analyse Structure of the human cytosolic sialidase NEU2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SNT
Type: protein
Length: 352 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sialidase 2
EC: 3.2.1.18
UniProt: Q9Y3R4
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sialidase 2 (EC 3.2.1.18)	protein	352	6% helix, 53% strand	Q9Y3R4

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	323	0.65	0.80	33	empty
2	97	0.36	0.74	21	empty

Compared structures

1SNT · Structure of the human cytosolic sialidase Neu2 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y3R4 · AlphaFold monomer V2.0 prediction for sialidase-2 (Q9Y3R4) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y3R4
Elsewhere: RCSB PDB 1SNT · PDBe 1SNT · UniProt Q9Y3R4

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