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Protease inhibitor

Analyse Protease inhibitor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SKZ
Type: protein
Length: 104 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antistasin
UniProt: P15358
Ligands: CL
Pockets: 2 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Antistasin	protein	104	7% helix, 21% strand	P15358

Ligands and binding sites

CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.32	0.77	13	empty
2	58	0.25	0.71	15	empty

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

1SKZ · Protease inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
P15358 · AlphaFold monomer V2.0 prediction for antistasin (P15358) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15358
Elsewhere: RCSB PDB 1SKZ · PDBe 1SKZ · UniProt P15358

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