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Cryo-EM structure of chicken gizzard smooth muscle alpha-actinin

Analyse Cryo-EM structure of chicken gizzard smooth muscle alpha-actinin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SJJ
Type: protein
Length: 1,726 residues
Chains: 2
Method: electron crystallography
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Actinin
UniProt: P05094
Pockets: 20 · best druggability 0.75

Structure

electron crystallography · 1 distinct chain · 63% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Actinin	protein	863	63% helix, 2% strand	P05094

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	987	0.75	0.78	79	empty
2	717	0.74	0.79	67	empty
3	609	0.71	0.79	50	empty
4	617	0.67	0.76	59	empty
5	261	0.63	0.81	27	empty

Interfaces

1 interface between chains.

A–B · 5340 Å² buried · 90 hydrogen bonds · protein-protein

Compared structures

1SJJ · Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin · the same entry in another collection · chain A against A, TM-score 1.00
P05094 · AlphaFold monomer V2.0 prediction for alpha-actinin-1 (P05094) · a predicted model of the same protein · chain B against A, TM-score 0.31

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05094
Elsewhere: RCSB PDB 1SJJ · PDBe 1SJJ · UniProt P05094

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