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Crystal structure of norwalk virus polymerase (triclinic)
Analyse Crystal structure of norwalk virus polymerase (triclinic) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SH0
- Type
- protein
- Length
- 1,005 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase
- EC
- 2.7.7.48
- UniProt
- Q70ET3
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase (EC 2.7.7.48) | protein | 502 | 42% helix, 17% strand | Q70ET3 |
| B | RNA polymerase (EC 2.7.7.48) | protein | 503 | 42% helix, 17% strand | Q70ET3 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1022 | 0.74 | 0.77 | 104 | empty |
| 2 | 647 | 0.69 | 0.78 | 59 | empty |
| 3 | 366 | 0.61 | 0.77 | 44 | empty |
| 4 | 403 | 0.55 | 0.73 | 48 | empty |
| 5 | 58 | 0.44 | 0.83 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 311 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1SH0 · Crystal Structure of Norwalk Virus Polymerase (Triclinic) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q70ET3
- Elsewhere: RCSB PDB 1SH0 · PDBe 1SH0 · UniProt Q70ET3
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