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Crystal structure of the viral zalpha domain bound to left- handed Z-DNA

Analyse Crystal structure of the viral zalpha domain bound to left- handed Z-DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1SFU
Type: protein + DNA
Length: 152 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-D(*T*CP*GP*CP*GP*CP*G)-3'; 34L protein
UniProt: Q9DHS8
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, D	5'-D(TCPGPCPGPCP*G)-3'	dna	6	—	—
A, B	34L protein	protein	70	46% helix, 14% strand	Q9DHS8

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	178	0.46	0.76	16	empty

Interfaces

3 interfaces between chains.

D–B · 350 Å² buried · 6 hydrogen bonds · protein-nucleic
C–A · 345 Å² buried · 3 hydrogen bonds · protein-nucleic
C–D · 323 Å² buried · 24 hydrogen bonds · nucleic-nucleic

Compared structures

1SFU · Crystal structure of the viral Zalpha domain bound to left-handed Z-DNA · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9DHS8
Elsewhere: RCSB PDB 1SFU · PDBe 1SFU · UniProt Q9DHS8

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